Sanosuke is a tall man with reddish-brown hair, he has various outfits, though the one he is most seen in is white and red, and he usually has bandages covering his hands and stomach. He has a scar on his stomach as a result of failed attempt to commit seppuku and he has goldish-brown eyes.
Harada is one of the most cheerful of the Shinsengumi, He is usually making jokes with his friend Shinpachi and loves to makes other smile when times are full of sadness and pain. He is very quick to get angry, but also very loyal and friendly. He prefer the spear to the sword. Sanosuke serves Kondo as personal adviser, in fact he always is been informative of everything and is a fencing master.
He has a very proud determination. He also loves to have fun with his buddies, but he has a temper. He’s just one of those big spirited people who enjoy living life and loves to make people around him be happy and at ease.
You will always see him hanging around with Shinpachi and Heisuke since they are really good friends, and because of their wild personalities, they were named: ‘The comedian trio’ by the other members.
He and Shinpachi are the only main members to not turn into a rasetsu. In the game, it is notable that he has a good ending compared to the other members of the Shinsengumi.
In the anime he and Shiranui develop a friendship bond, the latter even willing to fight for humans to help his friend.
Sanosuke is fatally wounded in episode 6 of the second season of the anime, as he and Shiranui defeat Koudou’s rasetsu army at Ueno. Noticing this, Shiranui asks him what he means to do next. To this he responds that he has to meet his friends in Aizu, before drawing this last breath. In the movie it shows that Shiranui goes to Aizu for the sake of his dead friend.